Showing posts with label mastectomy. Show all posts
Showing posts with label mastectomy. Show all posts

Monday, June 15, 2015

Around the Web: Like Clockwork

I've been chewing my nails something fierce lately, and I haven't been able to put my finger on why (no pun intended). Then it hit me when the scheduler from my oncologist's office called this morning: I am due for my three-month scans.

Except this time I'm not having three-month scans. I got bumped to every four months, which apparently in my world is just going to mean an extra month of anxiety. My body is that well-adapted to this cycle. My brain knows just when to start acting on-edge, when nightly Xanax pills might be in order once again. After all, I've been doing this for almost four years now.

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It's like clockwork over here.

Except it isn't.

So now I'm all thrown off schedule, my right thumbnail is bitten to the quick, and I do have scans on the books five weeks from now. So I better figure out how to get this anxiety under control because I can't take five weeks on high alert. I will literally run out of nails.

I also made the mistake of mentioning this article from last week's round-up to my doctor by way of his assistant, and so my doctor promptly ordered a bone density scan for me. I've never had one, so this will provide a baseline. It is also, predictably, adding to my anxiety. I don't know if it's cancer, or parenthood, or just being in my mid-thirties, but my mind worries about every possible thing that could go wrong, and not just when it comes to scans (from our toaster catching fire, to getting car-jacked at a stoplight because of course, to sinkholes even though we live in Arizona not Florida. The list goes on.)

Anyhow, here's what I saw around the web this week (but I'm not asking my doctor about any of them, lest he order any more tests for me).

At Long Last, Answering Some Questions about 'Exceptional Responders'

"Silva is what researchers call an “exceptional responder,” the rare patient who has a surprising, dramatic response to a drug. . .

Silva’s story, and those of other exceptional responders, have led to an intriguing set of questions: Could researchers use technologies such as genetic sequencing to figure out what made Silva’s tumor respond to treatment? Could they mine that data for clues that might help other patients? Could they ultimately find a way to make the exceptional more routine?"

Actually, I'd happily submit to more tests if it was to figure out why I've been so lucky, why I've responded to drugs the way I have, and maybe lead to answers that could pass some of that luck on to someone else. 

Last Week it Was the Bones, This Week the Lungs?

"Scientists at the University of Edinburgh said they have discovered a “trigger” that allows breast cancer cells to spread to the lungs. . .

Prof Jeffrey Pollard, the centre’s director, said: “Our findings open the door to the development of treatments that target the tumour microenvironment, which may stop the deadly progression of breast cancer in its tracks.”"

Will the Breast Cancer Test Kit be Next to the Pregnancy Tests at the Drugstore?

"Researchers at the Department of Obstetrics and Gynecology of the Medical Center -- University of Freiburg have developed an approach for detecting breast cancer by means of urine samples. The method involves determining the concentration of molecules that regulate cell metabolism and that are often dysregulated in cancer cells. These molecules, referred to as microRNAs, enter into the urine over the blood. By determining the composition of microRNAs in the urine, the scientists succeeded in establishing with 91 percent accuracy whether a test subject was healthy or diseased."

A Case of Two Steps Forward, One Step Back (Or Sideways...)

"Countering previously held beliefs, researchers at The University of Texas MD Anderson Cancer Center have discovered that inhibiting the immune receptor protein TLR4 may not be a wise treatment strategy in all cancers. This is because TLR4 can either promote or inhibit breast cancer cell growth depending on mutations in a gene called TP53. . .

"This looks like a promising avenue to develop drugs for the worst kinds of cancers," says Brown. "However, if we wish to target this immune pathway, we better pay attention to the TP53 status of the tumor.""

Finding Relief from Post-Mastectomy Pain

Mine is not so much pain as it is a significant tightness throughout my right pectoral muscle and armpit region (to use the anatomically correct term, I'm sure) that no amount of stretching seems to alleviate (although yoga helps tremendously). Chris, if you're reading, I think monthly spa massages would help, too.

My goal {photo credit}
"“Pain is a psychological trigger for worry about cancer recurrence,” said Julie Silver, an associate professor at Harvard Medical School who specializes in cancer rehabilitation. “Treating PMPS really helps to relieve that anxiety.”

PMPS is generally defined as nerve-related pain that persists for at least three months after breast cancer surgery, though it can take up to six months to develop. It tends to occur in the upper chest or the underside of the arm, causing pain that women often describe as burning or shooting, and it sometimes presents, as it did in my sister, as an unbearable itch."

I Might Have to Ask My Doctor About A Daily Aspirin Regimen

He can't order any tests based on a question about aspirin, can he? 

"A daily dose of aspirin may be effective at blocking breast tumour growth, Indian-origin researchers have claimed.

Dr Sushanta Banerjee, research director of the Cancer Research Unit at the Kansas City Veterans Affairs Medical Center, and his team found that aspirin may be able to ensure that conditions around cancer stem cells are not conducive for reproduction."

And How Law School May Have Led to My Cancer Diagnosis*

"“People really should elevate the importance of sleep to the same level they do diet and exercise to improve their overall health and well-being,” he said."

On that note, I'm going to bed. 

* Allegedly.

Friday, August 1, 2014

Around the Web

We're in Northern California for Chris' 20-year high school reunion, which happened to coincide with the Sonoma County Fair. Next week, we'll be in Portland. Chris has a conference for work, and one of my best friends lives there. This guy and I are so happy to be out of Phoenix when it is 113 degrees.

We return just in time for another round of chemo for me on the same day I have my next scan and an EKG to make sure my heart is holding up to all these meds. I'm hoping the vacation will keep me from getting too anxious about the scan. I'll let you know how THAT pans out.

Anyway, here's what I found on the web this week.

A New Approach to Treating Cancer?

"Doctors need to ascertain which cell subgroups are truly driving the tumor’s growth and metastasis and select drugs that target the critical genes within those cells. It can be a mistake to assume that the largest, most dominant subgroup is the one to be targeted."

This Story Hit Close to Home

I would argue that having a toddler around helps make chemo bearable. It's hard to focus on how terrible you feel when you've got a child demanding that you build train tracks or watch another episode of Curious George with him.

Why Some Women Opt for Mastectomies (It's Not Just About Survival)

This story also hit close to home. 

Can Doctors Teach the Body to Cure Cancer?

More on immunotherapy and the future of cancer treatment.

Have an article you think I should include here? Email me at jen (dot) campisano (at) gmail. 

Thursday, July 17, 2014

Around the Web

I've about recovered from the beating my body took last weekend. I admit I haven't been monitoring the headlines as closely as usual between walking almost forty miles and traveling with a toddler. But here's what caught my attention on the web last week.

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Researching targets for triple negative breast cancers

"If her approach is successful, we may have a new way to deliver drugs with precision: not just to cancer cells, but to any type of diseased cell or organ with a distinctive pattern of proteins on the surface."

And some not-so-great news from the clinical trial world.

"The long-awaited results showed that adding lapatinib [Tykerb] to adjuvant trastuzumab [Herceptin], either concurrently or sequentially, does not increase disease-free survival compared with use of trastuzumab alone in women with early-stage HER2-positive breast cancer."

We may someday be able to predict who will benefit from Tamoxifen. . .

. . . eliminating unnecessary side effects for so many women.

"A gene signature identified using a new approach has the potential to be used in the clinic to predict which patients with estrogen receptor-positive breast cancer will benefit from tamoxifen therapy after surgery, according to data published in Cancer Research, a journal of the American Association for Cancer Research."

And what if we eliminate hormone receptors altogether?

New developments for treating estrogen-receptor positive breast cancer from one of my favorite companies, Genentech.

More research suggesting we are overdoing it with mastectomies

"'Most patients have very minimal increases in life expectancy, one to seven months," Tuttle said. And that difference was spread over two or more decades, especially in the younger women, he said."

No regrets here.

Finally, are antioxidants harmful to cancer patients? 

Let the conversation begin (or continue). When I was seeing my naturopath regularly, he suggested I have infusions of Vitamin C to combat cancer growth, but my oncologist strongly advised against it. I went with my oncologist, and now I'm rethinking the supplement I add to my occasional morning smoothie, too. Do you take supplements? What are your thoughts on antioxidants? Does this study change your mind at all?


Tuesday, May 27, 2014

Around the Web

Here's what caught my (and my friend Kathryn's) attention this week.

Remember my swimsuit post? And then there are these.

I love the idea of a few of these in theory. Some I call a big bluff on; that last one is not so much a swimsuit as an ice-dancing competition costume inspired by "Mad Max." Either way, I'm pretty sure I would never be brave enough to carry off any of these looks in public. (Also, depending on your office, some of these might be considered NSFW. Just so you're prepared.)

Could the solution to breast cancer really be so simple?

"We believe that it might be possible to treat breast cancer — the leading cause of female death — with a drug that can already be found in nearly every medicine cabinet in the world: Aspirin.

In 2010, we published an observational study in The Journal of Clinical Oncology showing that women with breast cancer who took aspirin at least once a week for various reasons were 50 percent less likely to die of breast cancer."

Stocking my medicine cabinet with Bayer tomorrow.

And not one, but TWO possible new breakthroughs for treating Her-2+ breast cancer.

Thanks to the lovely Kathryn for the second article. These studies are so promising. As the Facebook page says, "I fucking love science."

I fall into the "I just wanted them to match" category.

If I had it to do over, though, knowing what I know now (mostly regarding numbness and phantom itching), I might have kept my healthy breast.
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"The number of women getting double mastectomies after a breast cancer diagnosis has been rising in the past 10 years, even though most of them don't face a higher risk of getting cancer in the other breast."

Now if researchers could just translate these findings to solid-tumor cancers like breast and lung cancer, I know a whole lot of people who would be thrilled.

And thanks, Kathryn, for this one, too. 

Wednesday, April 23, 2014

Swimsuit Season

I know, I know--some of you are still wondering whether it's finally, really okay to put the snow shovels away for the season, and here I am about to talk about swimsuits. What am I? Heartless? I can't help it, you guys. It is NINETY-SEVEN DEGREES here today, and that is not a fluke, not a one-day oopsie-daisy. We are this close to triple digits, which means we are also this close to swimming pool weather. Right now, the water is still just a tad too cold because the air still cools down into the 50s/60s at night here. Come August, the pool will feel like a hot tub and I'll be begging Chris for a plane ticket to Seattle.


A couple of years ago, I bought a few bikinis at Target. I didn't give much thought to them because I was just happy to be healthy enough to enjoy the water with Quinn, to vacation in Mexico with him and Chris. I had my expanders in then, and despite their coconuts-on-a-board appearance, I was hardly self-conscious because I was alive. People could think I got a terrible boob job--let them! I thought.

After a couple of years of sun and chlorine and toddler tugging, my Target swimsuits need replacing, and suddenly I am feeling very stuck. I'm self-conscious about the port in my chest (whereas it didn't even cross my mind a couple years ago), so I'm looking at halter styles or a one-shouldered suit that might strategically hide the darn thing. I'm anxious about sun exposure post-radiation, so luckily rash guards are everywhere. I used to gravitate toward string bikinis because you can adjust them so there are no unnecessary lumpy parts, but I'm second-guessing myself with Quinn, who is at perfect string-pulling height.

And then I think: I'm being ridiculous and should just wear whatever stays put best with a toddler climbing on me in the water. Your kids do that too, right? Use your bikini bottoms as a step-stool? 

I picked out a couple of suits at Target last weekend to get me through the first few pool days, but the only one that fit is a total mom suit. "I'm sure you can do better than that," Chris told me. A mom at Quinn's swimming lessons recommended Victoria's Secret, but that seems too...spring-breaky, too young, too sexy for what I've got in mind. I've browsed online at J. Crew, Athleta, and Canvas by Land's End, but nothing is grabbing me, although I've gone back to these ones for a second glance. 
Clockwise from top: 1 2 3 4 5 6
And it is wonderful to occupy my brain with something so trivial as a new swimsuit. I do realize this. Don't fret: I have scans coming up in a couple of weeks, so I'll get back to discussing my anxiety and mortality soon enough. 

But seriously, I'd love your thoughts. Where else do you shop for suits that are reasonably-priced? Do more expensive suits hold up longer? If you've had a mastectomy/reconstruction or a port, does that affect your swimsuit style? Does having kids influence your choice of swimwear? Because I'm thinking I won't be such a jungle gym in a one-piece. And do you hate me for mentioning pool weather this early in the year, after the winter most of you have had?