Friday, September 12, 2014

Around the Web

If I'd read nothing else on the internet this week, it would have been okay. The first article (below) alone would have been enough. Tomorrow is my thirty-sixth birthday, and this felt like a little bit of an early birthday present, even if it is only Phase 2 and still likely has a couple of years before FDA approval, assuming Phase 3 goes as well as this one did. There are a lot of ifs. But so many, many thank you's from the bottom of my heart to the researchers who are letting me celebrate more birthdays.

Vaccine for Her-2 Positive Breast Cancer Shows Promise

"Women with HER2 +3 who were administered trastuzumab [Herceptin] as part of the standard of care prior to receiving the vaccine experienced no cases of cancer recurrence."

Not from The Onion: Bras Don't Cause Breast Cancer

I can't believe someone got funded to study this.

Male Orangutan Dies of Breast Cancer

"Eli was diagnosed with breast cancer in 2011. Zoo veterinarians have monitored him closely since then, said spokeswoman Erica Hansen, in part because cancer is rare in orangutans. He was the only male known to have it, along with two females."

A Perspective on "Battle" Language

I am definitely guilty of personifying cancer. The name of my blog is Booby and the Beast, after all. I've talked about hunting down and eradicating cancer cells. I've compared chemo to smart-bombs. But I don't know that any of what I've done is brave, certainly not heroic. I'm just not sure how else to talk about living with cancer. I thought this post was excellent food for thought. 

"And I don’t want anyone at my funeral saying, “She fought bravely.” Because really, who doesn’t?"

But Speaking of Brave...

A teenager shares his cancer journey in pictures on Instagram.



Friday, September 5, 2014

Around the Web

Here's what I found on the internet this week. All of these advances, and we're still losing too many people to cancer. Please hurry, science.

{photo credit}

Harnessing the Immune System to Stop Melanoma

Yesterday, Merck received fast-track approval for a drug that boosts immune cells to fight melanoma.

"Merck is also studying pembrolizumab against a type of lung cancer, advanced head and neck cancer and late-stage bladder cancer."

Related: An Association Between Melanoma and Breast Cancer Risks

This was on the local news Monday night. It's just one more reason for me to be even more paranoid about every little dot on my skin, especially after my dad's bout with melanoma two years ago. Time to make that annual appointment with my dermatologist.

More Research into How Cancer Metastasizes, And (Maybe) How to Stop It

Unfortunately, drug inhibitors likely won't be available for five to ten years. Seriously, please hurry up, science.

How Much is a Year of Life Worth?

A follow-up from last week's article about the shake-up in what drugs the UK's health system will continue to cover (or not).

Liquid Biopsies -- Coming Soon to a Doctor Near You?

“'By repeating these blood tests regularly, they may give us a very accurate understanding of whether someone is responding to their treatment or not — which is very important for a woman to understand.

'She doesn’t want to be on a treatment that’s not working, or be exposed unnecessarily to side-effects, when she could be switched to a therapy that could be more effective,' Dr Dawson said."

Men Get Breast Cancer, Too -- But Could These Cases Have Been Prevented?

A look into whether the drinking water (or other contamination) at a U.S. Marine Base is causing cancer, and this man's untimely death

Wednesday, September 3, 2014

Negative Space

I am not a morning person, despite how much I love to watch the sun rise. I prefer to work late. I would workout after noon every day if schedules and temperatures allowed. But even by my scale, I woke up feeling especially irritable on Monday this week. My head hurt. I hadn't gotten enough sleep. It was a holiday, so I felt like I should have been relaxed, but I just couldn't find it. I was on edge and testy, and when Quinn asked me to play with him, I practically begged him to let me read to him on the couch instead while I finished my coffee. 

Last week, I'd been chatting online with a friend of mine, Renee, another mom with metastatic breast cancer. She'd run into our friend Brigid at chemo last Tuesday. They have the same oncologist and it wasn't unusual for them to see each other at the infusion center. I wanted to know how Brigid was, how she looked. I was hoping to get out to see her at her next appointment, in two weeks.

Monday afternoon, I got this text from Renee: "My heart is broken." And I knew.

I immediately checked Facebook and the first post in my feed was from Brigid's husband, on her account, letting us all know that she passed away Monday afternoon, after eight years of living with breast cancer. He said he'd never been more proud of anyone in his life. I couldn't help but think about what I hoped Chris would never have to write on my wall.

I've been thinking and thinking about what to say about Brigid here, if anything. We weren't especially close, not in the way that I am with my oldest friends or the people I see every week. But there is an instant understanding when you meet someone who's had the same surgeries you've had, who has suffered the side effects of the drugs you're on, who knows what it's like to be bald more than once, who can commiserate about the never-ending cycle of scans and treatment and hope for a better option. Cancer, in its ugliness and brutality, creates intense bonds. I couldn't not write about Brigid. 

When I was diagnosed, she was one of the first people who gave me hope about what it means to live with metastatic breast cancer. In one of our early conversations, I asked her how she stayed so positive (the girl always had a smile on her face). She answered plainly, "I've never felt sick." I'm sure that changed over the past few months, as her cancer changed course and her treatments became more harsh, but her smile never faded.

I, on the other hand, can hardly bring myself to smile before my second cup of coffee.

{an early meeting with Brigid (center) and our friend Patti}
***

In her book Tiny Beautiful Things: Advice on Love and Life from Dear Sugar, Cheryl Strayed (of Wild fame) wrote: 
One of the basic principles of every single art form has to do not with what's there--the music, the words, the movement, the dialogue, the paint--but with what isn't. In the visual arts it's called the "negative space"--the blank parts around and between objects, which is, of course, every bit as crucial as the objects themselves. The negative space allows us to see the nonnegative space in all its glory and gloom, its color and mystery and light. What isn't there gives what's there meaning. Imagine that.
In Brigid's absence is a void, a negative space that reminds us of the "color and mystery and light" of the life she led. Of the brilliance that she shone on everyone she met. This isn't a perfect analogy, of course, because we are not better with her gone, but I am better for having known her. She did give what's here meaning. Brigid was small, only 4'11", so maybe it's fitting that words from this book resonated with me when I learned she'd died. Brigid was herself a tiny beautiful thing. 

Friday, August 29, 2014

Around the Web

{photo credit}
Here's what I found on the web this week. Every week, I hope it will be the cure, but I do believe we are getting closer. Let's just get there faster.

Is This Why Brain Mets Occur? Is This How We Can Stop Them?

"Now Memorial Sloan Kettering researchers have found that a protein called cathepsin S may play a key role in the spread of breast cancer to the brain. A complex interplay between breast cancer cells and certain surrounding cells called macrophages induces both cell types to secrete increased levels of cathepsin S, an enzyme that promotes the cancer cells’ ability to metastasize.

In addition to potentially helping doctors predict which breast cancer patients are at increased risk for brain metastasis, the discovery, published recently in Nature Cell Biology, suggests that cathepsin S could be an important target for new drugs."

Why We Need More Words to Describe Living with Cancer

What words do you use to describe your breast cancer journey? Battling? Thriving? Surviving? Suffering? Treating? All of the above? 

For the most part, I think to each her own when talking about cancer and otherwise, but I do think the author here is right: Amy Robach, by virtue of her position as a journalist, has a special responsibility to choose her words more carefully.

Public Service Announcement: Pfizer Initiates Expanded Access Program for Treating Certain Advanced Breast Cancers

"Under its expanded access programs, the U.S. Food and Drug Administration (FDA) works with companies to allow access to investigational therapies to patients with serious or life-threatening illnesses who do not otherwise qualify for participation in a clinical trial and for whom there are no comparable or satisfactory alternate therapies."

This particular drug, palbociclib, is for hormone-positive, HER-2-negative breast cancer patients.

Breast Cancer is Really (at Least) 10 Different Diseases

While it's inspirational to hear, "My aunt had breast cancer 10 years ago and is doing great now!" it probably doesn't have any bearing on how someone else diagnosed with breast cancer today is going to fare. As I keep reminding myself when I see my friends dying -- whose cancer is, on paper, very similar to my own -- every disease blueprint is unique.

How Much is a Cancer Drug Worth? The UK is Reevaluating.

"Big manufacturers set to be affected by the changes include Roche, which came under fire this month from Nice [National Institute for Health and Care Excellence] for failing to cut the price of Kadcyla. The £90,000 per course drug is for women with advanced breast cancer. Nice rejected the drug as failing to offer value for money at that price."

I am eternally grateful for the quality of my health insurance.

Monday, August 25, 2014

Milestones

Quinn was five months old when I was diagnosed with Stage 4 breast cancer. At the time, the statistics I could find (when I dared to look) said about twenty percent of people with metastatic breast cancer would make it to the five-year mark. I couldn't help myself; I equated that statistic with me having a one in five chance of watching my son start kindergarten.

Kindergarten is still two years away. I am not there yet. But I am doing exceptionally well (knock on so much wood).

Quinn started preschool this week, after a short summer break and at the same school he's been attending since last October. School -- if you can call it that -- is not exactly new for him, but he has a new teacher with new friends to make. We bought him a new lunchbox, green with dinosaurs on it.

A lot of the moms of kids in Quinn's preschool are starting to chat about which school our kids will go to for kindergarten, and, slowly, I've found myself joining the conversation. I've spent the last couple of nights (crazy wild weekend here!) researching charter schools and open enrollment options for the public elementary schools in the districts next to ours. Although we love our house and neighborhood, we are nestled between two excellent public school districts. Ours, on the other hand, is just okay. I'm not sure I'm willing to accept "just okay" in a state with one of the worst public education systems in the country.

A lot can happen in two years. Cancer is a sneaky and unpredictable beast, and I still live in three-month increments. But as I was reading about different charter schools' philosophies late last night, it dawned on me that -- sure enough, statistics be damned -- I am starting to make actual, real-life plans to be here for Quinn's elementary school years. I am letting myself believe this could really happen.

We also bought Quinn a big boy bike this weekend. At REI, we couldn't get him off the darn thing. For at least half an hour, he wound his way expertly through tent displays and racks of clothing and the rock-climbing gear. He paused to check out the ropes hanging from the ceiling. "One sport at a time," I cautioned him as he tried to pull himself up by the carabiners.

And then I caution myself because I don't want to jinx anything: one milestone at a time.